March

When you double-click an Excel workbook or a shortcut to an Excel workbook, Excel starts. However, the Excel workbook does not open, and you receive an error message.
The typical fix is usually kb/211494 however occasionally it will not work.

I discovered the issue was actually in the profile and deleted the users profile.

You can do it with the User Profiles dialog in System Properties:

• Log in as different user (with admin privileges) than you want to delete
• Open Properties for Computer
• Advanced system settings (on the left side)
• Settings for User Profiles (in the middle)
• Select the profile you want to delete and click the delete button

Now you need to delete the profile in the Registry

To clear user local profile via registry:

1. Press on Start > Run >Regedit

2. Navigate to the following registry key :“HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\Windows NT\CurrentVersion\ProfileList”

3. Under ProfileList navigate to binary key’s like this: S-1-5-21-3656904587-1668747452-4095529-500

4. On the right side under ProfileImagePath you'll see the profile path.

5. Chose the one with the desired user and delete the long registry key like: “HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\Windows NT\CurrentVersion\ProfileList”